We are pleased to inform you that a meta-analysis of capecitabine effect as part of neo-/adjuvant chemotherapy including 15,993 patients from 13 randomized trials has been published in European Journal of Cancer.
The aim of this study was to examine the effect of capecitabine on disease-free survival (DFS), distant DFS (DDFS) and overall survival (OS) in early breast cancer in an individual patient data meta-analysis and to investigate whether biological subgroups exist that benefit from capecitabine treatment in the entire cohort and in subsets of patients in which capecitabine was used either in addition to another therapy or in which capecitabine was used instead of another therapy. Individual data from 15,993 patients from 13 randomized trials were analyzed.
Conclusion: Capecitabine was able to improve DFS and OS in patients with TNBC and in all patients with early breast cancer when administered in addition to systemic treatment.
an Mackelenbergh MT, Seither F, Möbus V, et al. Effects of capecitabine as part of neo-/adjuvant chemotherapy - A meta-analysis of individual breast cancer patient data from 13 randomised trials including 15,993 patients. Eur J Cancer. 2022 May;166:185-201. doi: 10.1016/j.ejca.2022.02.003.